This volume presents perspectives on spatially construed knowledge systems and their struggle to interrelate. Western social sciences tend to be wrapped up in very specific, exclusionary discourses, and Northern and Southern knowledge systems are sidelined. _Spatial Social Thought_ reimagines the social sciences as a place of encounter between all spatially bound, parochial knowledge systems.

In this creative and engaging reading, Richard Kuhns explores the ways in which _Decameron's_sexual themes lead into philosophical inquiry, moral argument, and aesthetic and literary criticism. As he reveals the stories' many philosophical insights and literary pleasures, Kuhns also examines _Decameron_in the context of the nature of storytelling, its relationship to other classic works of literature, and the culture of trecento Italy. Stories and storytelling are to be interpreted in terms of a wider cultural context that includes masks, metamorphosis, mythic (...) themes, and character analysis, all of which Boccaccio explores with wit and subtlety. As a storyteller, Boccaccio represents himself as literary pimp, conceiving the relationship between storyteller and audience in sexual terms within a tradition that goes back as far as Socrates' conversations with the young Athenians. As a whole, Boccaccio's great collection of stories creates a trenchant criticism of the ideas that dominated his social and cultural world. Addressed as it is to women who were denied opportunities for education, the author's stories create a university of wise and culturally observant texts. He teaches that comic, religious, sexual, and artistic themes can be seen to function as metaphors for hidden and often dangerous unorthodox thoughts. Kuhns suggests that _Decameron_is one of the first self-conscious creations of what we today call "a total work of art." Throughout the stories, Boccaccio creates a detailed picture of the Florentine trecento cultural world. Giotto, Buffalmacco, and other great painters of Boccaccio's time appear in the stories. Their works and the paintings that surround the characters as they prepare to leave the plague-ridden city, with their representations of Dante, Aquinas, and other thinkers, are essential to understanding the ways the stories work with other works of art and illuminate and enlarge interpretations of Boccaccio's book. (shrink)

The problem of free will lies at the heart of modern scientific studies of consciousness. Some authors propose that actions are unconsciously initiated and awareness of intention is referred retrospectively to the action after it has been performed [e.g. Aarts, H., Custers, R., & Wegner, D. M. . On the inference of personal authorship: Enhancing experienced agency by priming effect information. Consciousness & Cognition, 14, 439–458]. This contrasts with the common impression that our intentions cause those actions. By combining (...) a stop signal paradigm and an intentional action paradigm we show that participants sometimes indicate to have intentionally initiated an action while reaction time data strongly suggest that they in fact failed to stop the action. In a second experiment we demonstrate that the number of trials in which participants misattributed their awareness of intention varied with the intentional involvement during action planning. Our data support the retrospective account of intentional action. Furthermore, we introduce an experimental approach that objectifies introspective judgments of awareness of intention. (shrink)

The significance of the plurality of the Copernican Revolution is the main thrust of this undergraduate text In this study of the Copernican Revolution, the ...

Ein Gespenst geht um in den Wissenschaften - das Gespenst des Gedankenexperiments. Gedankenexperimente verheißen Erkenntnisgewinn ohne empirische Arbeit - was vor dem Selbstverständnis der modernen Naturwissenschaften jedoch einer Unmöglichkeit gleichkommt. Und doch zieht sich das Forschen mit Gedankenexperimenten wie ein roter Faden durch die lange Tradition in den empirischen Wissenschaften von ihren Anfängen bei Stevin, Galilei und Newton bis heute.

Ethical evaluation of deep brain stimulation as a treatment for Parkinson’s disease is complicated by results that can be described as involving changes in the patient’s identity. The risk of becoming another person following surgery is alarming for patients, caregivers and clinicians alike. It is one of the most urgent conceptual and ethical problems facing deep brain stimulation in Parkinson’s disease at this time. In our paper we take issue with this problem on two accounts. First, we elucidate what is (...) meant by “becoming another person” from a conceptual point of view. After critically discussing two broad approaches we concentrate on the notion of “individual identity” which centers on the idea of “core attitudes”. Subsequently we discuss several approaches to determine what distinguishes core attitudes from those that are more peripheral. We argue for a “foundational-function model” highlighting the importance of specific dependency relations between these attitudes. Our second aim is to comment on the possibility to empirically measure changes in individual identity and argue that many of the instruments now commonly used in selecting and monitoring DBS-patients are inappropriate for this purpose. Future research in this area is advised combining a conceptual and an empirical approach as a basis of sound ethical appraisal. (shrink)

The present review on dyadic coping (DC) aims at providing a critical integration of both the conceptual and empirical DC literature and overcoming the limitations of past reviews by (a) describing, comparing, and integrating all the DC models, (b) presenting and integrating findings from studies based on DC models, and (c) suggesting directions for further research. The DC models identified and compared include: The congruence model (Revenson, 1994), the relationship-focused model (Coyne & Smith, 1991; O’Brien & DeLongis, 1996), the communal (...) coping model (Lyons, Mickelson, Sullivan, & Coyne, 1998), the systemic-transactional model (Bodenmann, 1995, 1997); the relational-cultural model (Kayser, Andrade, Watson, 2007), and the developmental-contextual coping model (Berg & Upchurch, 2007). After discussing each DC model, we advance a conceptual integration of all models, which serves as the framework to organize the review of the empirical literature. This integration includes the following DC dimensions: (a) Stress Communication, (b) Positive DC by One Partner (supportive DC, empathic responding, delegated DC, active engagement), (c) Positive Conjoint DC (common, collaborative, communal, mutual responsiveness); (d) Negative DC by One Partner (protective buffering, overprotection, and hostility/ambivalence), and (e) Negative Conjoint DC (common negative DC, disengaged avoidance). Developmental, relational, and contextual variables are included as factors shaping DC. To be included in the empirical review, articles had to be published in or a peer-reviewed journal in English and/or German before 2017 and include an original empirical study guided by one of the DC models. The review included 139 studies and, with the exception of CM whose findings were discussed separately, findings were presented for overall DC and each of the dimensions identified in the conceptual integration. Findings were grouped also according to whether the stressor related or not to a medical or mental health condition. Demographic and cultural factors affecting DC were discussed. Overall, the empirical review suggests that in Western couples, positive individual and conjoint DC forms, taken together or separately, have individual and relational benefits for couples coping with stress in general and/or mental health or medical stressors. Research on DC can be expanded to include other populations and stressors and use improved designs. (shrink)

This compelling study of the origins of all that exists, including explanations of the entire material world, traces the responses of philosophers and scientists to the most elemental and haunting question of all: why is _anything_ here—or anything _anywhere_? Why is there something rather than nothing? Why not nothing? It includes the thoughts of dozens of luminaries from Plato and Aristotle to Aquinas and Leibniz to modern thinkers such as physicists Stephen Hawking and Steven Weinberg, philosophers Robert Nozick and (...) Derek Parfit, philosophers of religion Alvin Plantinga and Richard Swinburne, and the Dalai Lama. The first accessible volume to cover a wide range of possible reasons for the existence of all reality, from over 50 renowned thinkers, including Plato, Aristotle, Aquinas, Descartes, Leibniz, Hume, Bertrand Russell, Stephen Hawking, Steven Weinberg, Robert Nozick, Derek Parfit, Alvin Plantinga, Richard Swinburne, John Polkinghorne, Paul Davies, and the Dalai Lama Features insights by scientists, philosophers, and theologians Includes informative and helpful editorial introductions to each section Provides a wealth of suggestions for further reading and research Presents material that is both comprehensive and comprehensible. (shrink)

Post-translational histone modifications and their biological effects have been described as a ‘histone code’. Independently, Barbieri used the term ‘organic code’ to describe biological codes in addition to the genetic code. He also provided the defining criteria for an organic code, but to date the histone code has not been tested against these criteria. This paper therefore investigates whether the histone code is a bona fide organic code. After introducing the use of the term ‘code’ in biology, the criteria (...) a putative organic code such as the histone code must conform to in order to be recognised as an organic code are described. Our current knowledge of histones and their major post-translational modifications, and the specific protein binding domains that recognise and translate these into specific biological effects, is then reviewed in detail. The histone modification system is then placed in the context of an organic code and it is concluded that it fulfils all the requirements of an organic code. The marks produced on histones by processes such as acetylation and methylation act as organic signs that are translated into unique biological effects, their biological meanings. These translations are accomplished by effector proteins that consist of a binding domain that recognises a specific histone mark and a regulatory domain that mediates the biological effect. Crucially, these domains can be experimentally interchanged between different effector proteins, thus altering the rules that specify the relationships between sign and meaning. The effector proteins therefore fulfil the role of adaptor molecules. (shrink)

La Philosophie de la religion demande une délimitation par rapport à des philosophies religieuses et la science religieuse. L'étude de quelques auteurs représentatifs montre ensuite une certaine convergence théorique autour du problème de la « contingence » dont la « maîtrise » socio-pratique implique aujourd'hui souvent tout le sens du « réel ». La tâche critique d'une philosophie de la religion consiste alors à plaider pour une ouverture des valeurs humaines vers l'« inconditionnel », et cela dans l'intérêt même d'une (...) « libertégénérosité » à sauvegarder. The Philosophy of religion requires demarcation comparatively to any religious philosophical thought and the science of religion. The study of several representative scholars points out that the problem of « contingency » is able at present to permit some conformity concerning theoretical positions. Frequently, the social and material « control » of this contingency of our world of life is forming the exhaustive sense of that what means « Reality » Therefore, it is a critical necessity of the philosophy of religion to demonstrate that human values are including orientation to an « inconditional ». (shrink)

Urban dwellers are more likely to develop mental disorders such as mood and anxiety disorder as well as schizophrenia compared to rural dwellers. Moreover, it has been demonstrated that even short-term exposure to nature can improve mood and decrease stress, but the underlying neural mechanisms are currently under investigation. In the present intervention study we examined the effects of a one-hour walk in an urban vs. natural environment on activity in the amygdala, a brain region previously associated with stress processing. (...) Before and after the walk 63 participants underwent an fMRI paradigm inducing social stress. Since there is a pronounced gap in the literature regarding interindividual differences in stress-related neural effects of urban and natural environments, we set out to explore sex differences. We observed that amygdala activity decreased after the walk in nature, but only in women, suggesting that women may profit more from salutogenic effects of nature. Moreover, performance on the arithmetic tasks improved in women after the walk in nature, whereas men performed better after the walk in the urban environment. To our knowledge, this is the first study to report differencial tendencies in men and women concerning the stress-related neural activity as an effect of acute exposure to urban vs. natural environments. Furthermore, our findings highlight the importance of sex differences when exploring effects of the environment on brain function and stress. Evidence for beneficial effects of nature on stress-related brain regions may inform urban design policies to focus on providing more accessible green areas in cities and this study suggests that sex differences in experiencing the environment should be taken into consideration. (shrink)

A distinctive feature of Ludwig Wittgenstein's work after 1930 was his turn to a conception of philosophy as a form of social inquiry, John G. Gunnell argues, and Thomas Kuhn's approach to the philosophy of science exemplified this conception. In this book, Gunnell shows how these philosophers address foundational issues in the social and human sciences, particularly the vision of social inquiry as an interpretive endeavor and the distinctive cognitive and practical relationship between social inquiry and its subject (...) matter. Gunnell speaks directly to philosophers and practitioners of the social and human sciences. He tackles the demarcation between natural and social science; the nature of social phenomena; the concept and method of interpretation; the relationship between language and thought; the problem of knowledge of other minds; and the character of descriptive and normative judgments about practices that are the object of inquiry. Though Wittgenstein and Kuhn are often criticized as initiating a modern descent into relativism, this book shows that the true effect of their work was to undermine the basic assumptions of contemporary social and human science practice. It also problematized the authority of philosophy and other forms of social inquiry to specify the criteria for judging such matters as truth and justice. When Wittgenstein stated that "philosophy leaves everything as it is," he did not mean that philosophy would be left as it was or that philosophy would have no impact on what it studied, but rather that the activity of inquiry did not, simply by virtue of its performance, transform the object of inquiry. (shrink)

A number of natural language constructions seem to provide access to structured pluralities — that is, pluralities of pluralities. A body of semantic work has debated how to model this additional structure and the extent to which it depends on pragmatics. In this article, after controlling for the distinction between ambiguity and underspecification, we present new data showing that structured pluralities are sometimes but not always available, depending on the form of the plural noun phrase used. We show that (...) these results challenge two longstanding theories of plurality. We sketch two different ways to account for these data and describe some of the diverging predictions they make. (shrink)

Like every other venerable speculation, philosophy has its myths and its great myth-makers. One of the greatest—maker of myths for all contemporary thought—was Kant. Should some future Lévi-Strauss classify this tradition, he will find that philosophical myths, like tribal lore of primitive peoples, suffer thematic variation and evolution, for myths relate our true business in this world, and therefore are essential for all thought about ourselves.

classical text"Second Thoughts on Paradigms.".

ObjectivesPhysical activity has been shown to protect executive functions against the deleterious effects of poorer sleep among older adults ; however, it is unknown whether memory is protected too, and if this relationship differs by age. The present study investigated the relationship between cardiorespiratory fitness, sleep, and memory in both older and young adults.MethodsThis observational study recruited 26 OA and 35 YA. Participants completed the Rockport 1-mile walk test to evaluate cardiorespiratory fitness. Participants wore an actigraph for 1 week to (...) measure habitual sleep and returned for a second visit to perform the memory tests. The interaction between cardiorespiratory fitness and sleep to predict memory was assessed separately in OA and YA.ResultsIn OA, cardiorespiratory fitness significantly moderated the relationship between memory and sleep quality, specifically number of nighttime awakenings, sleep efficiency, and wake after sleep onset. Further analyses reveal that a high number of nighttime awakenings and low sleep efficiency significantly predicted worse memory performance in the low fit OA, but high fit OA. Notably, every nighttime awakening was associated with a nearly 4% decrease in memory in low fit OA, but not high fit OA. Wake after sleep onset did not significantly predict memory in either fitness group. No interaction was found when looking at sleep duration or self-report sleep quality in OA and no significant interactions were observed between fitness, sleep, and memory in YA.ConclusionOverall, the results suggest that cardiorespiratory fitness may act as a protective buffer for memory in OA with poor sleep quality. These same was not true for YA suggesting that the protective effects of cardiorespiratory fitness on sleep-related memory impairments may be age specific. (shrink)

In the past, the European social sciences labelled and discredited knowledge that did not follow the definition for scientific knowledge as applied by the European social sciences as an alternative concept of knowledge, as “indigenous” knowledge. Perception has changed with time: Not only has indigenous knowledge become an entrance ticket to the European social science world, but the indigenization of European theories is seen by some as the contribution of “peripheral” social sciences to join the theories of the “centers”. This (...) book offers contributions to the discourses about alternative concepts of knowledge, inviting the reader to decide if they are alternative, indigenous, or European types of knowledge. However, in order to make this decision, the reader must know what the nature of the European concepts of science and of scientific knowledge is; this might be a motivation to read a book that presents thoughts claiming to be alternative concepts of knowledge, alternative to the European concept of science. (shrink)

This observation applies, e.g., to ancient Scepticism. The negation--the thesis of the unattainability of reliable truth--is the counterpart to the affirmative idea of an art of living practiced best by one who suspends judgment. It applies equally to Kant. Metaphysical competency is denied to reason in order to make room for faith. We find the same dialectic in existentialist philosophy. The negation, in this case, is of utmost radicalism and so is the corresponding affirmation. Hence the movement of thought from (...) pole to pole is of unparalleled vehemence. (shrink)

Wittgenstein’s laconic observation about self and history elicits thought about the interventions of history into our private consciousness. Although “the world” may end with the end of my consciousness, I could hardly claim that my consciousness exhausts the world, or that there are no presences, realities, objects, and events that do not come into my consciousness from elsewhere, creating for me a distinct ever-present awareness of mine and other, inner and outer, recollection and recognition. A plaintive refrain, similar to that (...) in Wittgenstein’s reflection, appears in much modern criticism that sets itself the task to understand and interpret works of art. Among such efforts there are theories whose main assumption is that a particular art, such as poetry, may indeed put forward a claim to the truth of an assertion, but it is not necessary to poetry as poetry that it asserts anything at all, and therefore it is irrelevant to poetry as poetry to be tested by reference to the world, to history, through the canons of verification and the principles of plausibility relevant to empirical inquiry. We might rewrite Wittgenstein’s aphorism this way: “What has poetry to do with the world? The poem is the first and only thing.”. (shrink)

Paradoxical images and understandings inherent in sustainable tourism discourses are identified as relating to two undergirding incongruities where humans and the environment are seen as discrete entities and inherently interrelated, and where humans and the environment are viewed as evolving over time, and as static and unchanging. To resolve these tensions, it is suggested that rather than taking an essentialist perspective, it is more useful to treat sustainable tourism as an aspiring evolving discourse. Recognition of human complicity in discourse construction (...) is proposed as necessary for fostering greater circumspection: thoughtful attention to the circumstances that reciprocally give rise to our own evolving consciousness and existential circumstances. (shrink)

This chapter contains sections titled: Introduction Comments about the Nature of Research Complexity Complexity and Educational Research Complexity in Educational Research: Caveats References.

Definition of the problem The COVID-19 pandemic poses a considerable challenge to the capacity and functionality of intensive care. This concerns not only resources but, above all, the physical and psychological boundaries of nursing professionals. The question of how care for others and self-care of nurses in intensive care units are related to each other in the context of the COVID-19 pandemic has not been addressed in public and scientific discourse so far. Arguments The present contribution reflects this relationship with (...) reference to the Code of Ethics of the International Council of Nurses, particularly considering principlism and the Care Ethics according to Joan Tronto. As a result, it shows a corridor of ethically justifiable care with several borders, above all: self-care must not be given up completely for the benefit of care for others, and a categorical subordination of care for others to self-care is ethically not justifiable. Conclusion The article makes an important contribution to a differentiated ethical consideration of the rights and responsibilities of intensive care nurses as moral actors within the pandemic in Germany. It, thus, provides a first starting point for a broad social and political discourse which is urgently needed not only during but also after the pandemic in order to improve the situation of intensive care nurses and those who are cared for. (shrink)

The beneficial effects of physical exercise on physical health and cognitive functioning have been repeatedly shown. However, evidence of its effect on psychosocial functioning in healthy adults is still scarce or inconclusive. One limitation of many studies examining this link is their reliance on correlational approaches or specific subpopulations, such as clinical populations. The present study investigated the effects of a physical exercise intervention on key factors of psychosocial functioning, specifically well-being, stress, loneliness, and future time perspective. We used data (...) from healthy, previously sedentary older adults who participated in a 6-month at-home intervention, either engaging in aerobic exercise or as part of a control group who participated in foreign language-learning or reading of selected native-language literature. Before and after the intervention, comprehensive cardiovascular pulmonary testing and a psychosocial questionnaire were administered. The exercise group showed significantly increased fitness compared to the control group. Contrary to expectations, however, we did not find evidence for a beneficial effect of this fitness improvement on any of the four domains of psychosocial functioning we assessed. This may be due to pronounced stability of such psychological traits in older age, especially in older adults who show high levels of well-being initially. Alternatively, it may be that the well-documented beneficial effects of physical exercise on brain structure and function, as well as cognition differ markedly from beneficial effects on psychosocial functioning. While aerobic exercise may be the driving factor for the former, positive effects on the latter may only be invoked by other aspects of exercise, for example, experiences of mastery or a feeling of community. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:116 HISTORY OF PHILOSOPHY Forms not only as objects of contemplation but as patterns of conduct. Presumably the "physicist " is not interested, as physicist, in completing the dialectical journey. So from a moral point of view he rests in opinion, even though his thought may be conversant with Forms. Gully does not like the idea that the philosopher has a privileged method; Plato "gives no proper reason why (...) one particular method or account is privileged" (p. 146).Methods of "collection and division," as developments within the dialectical method, are discussed in the later dialogues, but they never take us to the end of the dialectical journey. Perhaps we should say that the modesty of Socrates in Books VI and VII of the Republic is prophetic. If one is looking for a completed theory of knowledge, one does not find it. Gulley is in agreement with this point, but he feels that if one wants to look for the area in which Plato could have settled on an adequate theory one will find it in the relationship of pure to applied mathematics. He says that Plato develops in his latest thought "a metaphysical theory restricted to the explanation of mathematical knowledge which provides a more satisfactory explanation of the distinction between a priori and empirical knowledge than does the theory of Forms" (p. 187). Yet with a suggestion of surprise he concludes, on Aristotle's testimony, that Plato 2id not "abandon the more general explanation.., which the theory of Forms provided." I 1o not think Gulley wishes to suggest that Plato should have seen the light as Gulley sees it, ~or Gulley conveys the impression of having confronted a puzzling fact. Some readers may be reassured in their efforts to lop off Level IV and commit it to the flames, but the author has presented his case with impartiality. ROBERT REIN'L Arizona State University Monopsychism, Mysticism, Metaconsciousness. Problems of the Soul in the Neo-Aristotelian and Neo-Platonic Tradition. By Philip Merlan. (The Hague: M. Nijhoff, 1963. Pp. 154.) Innerhalb der Metaphysik liilit sich ein Kreis yon zentralen Fragen abgrenzen und durch den Titel "Noetik" bezeichnen. Wie ist der Mensch zur Erfassung des Seins oder des Absoluten (oder wie sonst der Gegenstand der Metaphysik bezeiehnet werden mag) ausgeriistet? Wie verhiilt sich dies ausgezeichaete VermSgen, mages po~ oder poS~,ro~7~K&oder intellectus oder Vernunft hei[3en, einmal zu seinem Gegenstand, sodann zu den tibrigen VermSgen der menschlichen Seele? Und sehliel]lieh: welehe Bedeutung hat die Be~tigung dieses VermSgens ffir die menschliche Praxis? Nach der Gliederung der Philosophie, wie sie im nach-kantischen Zeitalter iiblich geworden ist, liil~t sich dieser Fragezusammenhang schwer lokalisieren. In die moderne Topologie gepresst, erscheint er als eine Verquickung yon erkenntnistheoretischer, ontologischer, psychologischer und religiiiser Problematik. Aber durehgehend ist der "noetische Bezug", will sagen die Ausriehtung auf die yon den Griechen als ~o~ (inteIlectus, Geist, Vernunft ) bezeichnete Kraft. Der Zugang zu der Fragestellung ergibt sich yon Plato her. Die Seele "bei sich selbst," abr,} ~aO' a~r~, d.i. in AblSsung vom Leib und der dutch ihn vermittelten Sinneswahrnehmung, schaut das An-sich-seiende, die eI~, und diese "reine" Erkenntnis wird verstanden als Wiedererinnerung yon vorgeburtlieh Erschautem. Schon bei der Geburt des Menschen findet sich also die Seele im Besitz yon ihr selbst nicht zug~nglichen Erkenntnissen. Bei Aristoteles lebt dieser platonische Gedanke in verwandelter Gestalt fort. Das VermSgen unmittelbarer, nieht-sinnlicher Erkenntnis, der vo~, verhiilt sich nach De anima III zu den,,,m~a (intelligibilia) wie die bei sich seiende Seele zu den "Ideen". Dies Erkennen aber unterscheidet sich nach Aristoteles yon aller diskursiven Erkenntnis dadurch, daft der Intellekt die Intigibilia ist, und dieses Eins-werden, modern gesprochen die Aufhebung der Subjekt-ObjektRelation, gibt der Kennzeichnung des Intellekts als "sch6pferisch" (~o~K6~, intellectus agens) ihren Sinn. Aueh darin folgt Aristoteles seinem Lehrer Plato, daI3 er den Gedanken des "Vorbesitzes ", will sagen der Unentstandenheit der intellektualen Erkenntnis beibehiilt. Aber er gibt ibm eine neue Wendung dadurch, daft er die Ananmesis ersetzt durch den Begriff des ~o~ als einer yon keiner Potentialit~it behafteten reinen, immer und yon je t~itigen b~p.ycta, eines "von aul3en" (~bpad~) in den Mensehen eingeftihrten gSttlichen Prinzips. BOOK REVIEWS 117... (shrink)

Self-injurious behavior is associated with diverse psychiatric conditions. Sometimes, SIB is the most dominant symptom, severely restricting the psychosocial functioning and quality of life of the patients and inhibiting appropriate patient care. In severe cases, it can lead to permanent physical injuries or even death. Primary therapy consists of medical treatment and if implementable, behavioral therapy. For patients with severe SIB refractory to conventional therapy, neuromodulation can be considered as a last recourse. In scientific literature, several successful lesioning and deep (...) brain stimulation targets have been described that can indicate a common underlying neuronal pathway. The objectives of this study were to evaluate the short- and long-term clinical outcome of patients with severe, therapy refractory SIB who underwent DBS with diverse underlying psychiatric disorders and to correlate these outcomes with the activated connectivity networks. We retrospectively analyzed 10 patients with SIB who underwent DBS surgery with diverse psychiatric conditions including autism spectrum disorder, organic personality disorder after hypoxic or traumatic brain injury or Tourette syndrome. DBS targets were chosen according to the underlying disorder, patients were either stimulated in the nucleus accumbens, amygdala, posterior hypothalamus, medial thalamus or ventrolateral thalamus. Clinical outcome was measured 6 months after surgery and at long-term follow-up after 10 or more years using the Early Rehabilitation Barthel index and time of restraint. Connectivity patterns were analyzed using normative connectome. Based on previous literature the orbitofrontal cortex, superior frontal gyrus, the anterior cingulate cortex, the amygdala and the hippocampus were chosen as regions of interest. This analysis showed a significant improvement in the functionality of the patients with DBS in the short- and long-term follow-up. Good clinical outcome correlated with higher connectivity to the amygdala and hippocampus. These findings may suggest a common pathway, which can be relevant when planning a surgical procedure in patients with SIB. (shrink)

How likely is it that traumatic childhood events are misremembered or forgotten? Research on children′s recollections of painful or frightening medical procedures may help answer this question by identifying predictors of accurate versus inaccurate memory. In the present study, 46 3- to 10-year-old children were interviewed after undergoing a stressful medical procedure involving urethral catheterization. Age differences in memory emerged, especially when comparing 3- to 4-year-olds with older children. Children′s understanding of the event, parental communication and emotional support, and (...) children′s own emotional reactions also predicted accuracy. Memory did not reliably vary for children who endured the medical procedure once versus multiple times. Results are discussed in relation to possible precursors of accurate and false memories, and forgetting, of traumatic events experienced in childhood. (shrink)

In aging humans, aerobic exercise interventions have been found to be associated with more positive or less negative changes in frontal and temporal brain areas, such as the anterior cingulate cortex (ACC) and hippocampus, relative to no-exercise control conditions. However, individual measures such as gray-matter (GM) probability may afford less reliable and valid conclusions about maintenance or losses in structural brain integrity than a latent construct based on multiple indicators. Here, we established a latent factor of GM structural integrity based (...) on GM probability assessed by voxel-based morphometry, magnetization transfer saturation, and mean diffusivity. Based on this latent factor, we investigated changes in structural brain integrity during a six-month exercise intervention in brain regions previously reported in studies using volumetric approaches. Seventy-five healthy, previously sedentary older adults aged 63–76 years completed an at-home intervention study in either an exercise group (EG;n= 40) or in an active control group (ACG;n= 35). Measures of peak oxygen uptake (VO2peak) taken before and after the intervention revealed a time-by-group interaction, with positive average change in the EG and no reliable mean change in the ACG. Significant group differences in structural brain integrity changes were observed in the right and left ACC, right posterior cingulate cortex (PCC), and left juxtapositional lobule cortex (JLC). In all instances, average changes in the EG did not differ reliably from zero, whereas average changes in the ACG were negative, pointing to maintenance of structural brain integrity in the EG, and to losses in the ACG. Significant individual differences in change were observed for right ACC and left JLC. Following up on these differences, we found that exercising participants with greater fitness gains also showed more positive changes in structural integrity. We discuss the benefits and limitations of a latent-factor approach to changes in structural brain integrity, and conclude that aerobic fitness interventions are likely to contribute to brain maintenance in old age. (shrink)

An overview is provided of how the concept of the thought experiment has developed and changed for the natural sciences in the course of the 20th century. First, we discuss the existing definitions of the term 'thought experiment' and the origin of the thought experimentation method, identifying it in Greek Presocratics epoch. Second, only in the end of the 19th century showed up the first systematic enquiry on thought experiments by Ernst Mach's work. After the Mach's work, a negative (...) attitude towards thought experiments came in the beginning of the 20th century, which went on until the Thomas Kuhn's and Karl Popper's work on thought experiments. Only from the mid-1980s did thought experiments begin to be considered relevant to scientific enterprise. Finally, we show the existing empirical and 'functional' theories which have developed about the nature and purpose of thought experiments. (shrink)

Over the past four decades, software engineering has emerged as a discipline in its own right, though it has roots both in computer science and in classical engineering. Its philosophical foundations and premises are not yet well understood. In recent times, members of the software engineering community have started to search for such foundations. In particular, the philosophies of Kuhn and Popper have been used by philosophically-minded software engineers in search of a deeper understanding of their discipline. It seems, (...) however, that professional philosophers of science are not yet aware of this new discourse within the field of software engineering. Therefore, this article aims to reflect critically upon recent software engineers’ attempts towards a philosophy of software engineering and to introduce our own philosophical thoughts in this context. Finally, we invite the professional philosophers of science to participate in this interesting new discourse. (shrink)

An examination of Russia's philosophical heritage. It extends from the Slavophiles to the philosophers of the Silver Age, from emigre religious thinkers to Losev and Bakhtin and assesses the meaning for Russian culture as a whole.

This paper seeks to redress the marginalization of Adorno in environmental philosophical discourse. Kate Soper describes two opposing ways of conceiving nature. There is the redemptive “nature-endorsing” paradigm that lays claim to the intrinsic value or “otherness” of nature. Conversely, the “nature-sceptical” approach denies that we can access originary, untouched nature. This paper argues that the significance of Adorno’s treatment of natural beauty lies in how he brings these approaches together. In writings that resonate with the dual connotations of Sebald’s (...) phrase “after nature”, Adorno both affirms the skeptical point that we cannot transcend a human history alienated from nature as well as retaining redemptive hope wherein art “after” nature seeks creative possibilities from out of the very ruins of history marked by nature’s destruction. (shrink)

The paper explores the relationships and interconnections in the philosophical and sociopolitical concepts of Günther Anders and Hannah Arendt. Both philosophers, who were married to each other for a short time, not only shared a similar fate in that they both had to flee from National Socialism, but both dealt with similar questions, albeit in different manners: with Auschwitz and the Holocaust, with the problem of totalitarianism, with the development of the Modern, which is defined by technology and industrial labour. (...) A comparison shows that many themes in the thinking of these philosophers are near to each other, but the methods and foci are other. At the foreground of Anders’ thinking is the question of the destructive influence of modern technology and weapons of mass destruction. However, Arendt concentrates on totalitarian political structures and the possibility of people to take action. Nevertheless, they both are concerned that people’s humanity is at risk under the political and technological conditions of the Modern. (shrink)